We performed a Citrus analysis on CD11b+CD11c+HLA-DR+ myeloid cells from the CD45+ viSNE island (Fig. 7a) and identified 29 separate cell clusters, only two of which were over-represented in COPD lungs (Fig. 7b, c and Supplementary Fig. 8). Here, ITGAM is linked to chronic obstructive pulmonary disease.