For example, MAPKAPK-2 (mitogen-activated protein kinase (MAPK)-activated protein kinase-2) and PKG1 (cGMP-dependent protein kinase 1), which are potential kinases for substrate #18, were identified as potential driver kinases involved in the development of clear cell renal cell carcinomas using peptide substrate microarray systems of fresh frozen tumor lysates without spatial information37. The gene discussed is MAPKAPK2; the disease is clear cell renal carcinoma.