MAPKAPK2 and neoplasm: For example, MAPKAPK-2 (mitogen-activated protein kinase (MAPK)-activated protein kinase-2) and PKG1 (cGMP-dependent protein kinase 1), which are potential kinases for substrate #18, were identified as potential driver kinases involved in the development of clear cell renal cell carcinomas using peptide substrate microarray systems of fresh frozen tumor lysates without spatial information37.