The findings that hepatic LCN2 expression closely correlated with disease severity (i.e. ABIC and MELD scores), the degree of portal hypertension (i.e. levels of HVPG) and the expression of key fibrogenic genes (i.e. COL1A1, TIMP1) highly suggest a pathogenic role for LCN2 in AH. The gene discussed is TIMP1; the disease is liver disorder.