Activation of this inflammasome occurs in response to multiple danger-associated molecular patterns including several molecules involved in the pathogenesis of type 2 diabetes: glucose, islet amyloid polypeptide, free fatty acids, and mitochondrial reactive oxygen species7,8, and leads to production of the mature forms of the proinflammatory cytokines IL-1β and IL-189. This evidence concerns the gene IL1B and type 2 diabetes mellitus.