CDH2 and meningioma: In contrast, analysis of meningioma cells in co-culture with human cerebral organoids after 12 h (Fig. 5h) and 14 days (Fig. 5i) revealed that organoid derived astrocytes also expressed CDH2 and PTPRZ1 (Fig. 5j, i), and that in contrast to monoculture conditions, meningioma cells in co-culture samples maintained CDH2 expression (Supplementary Fig. 6e) and increased PTPRZ1 expression over time (Supplementary Fig. 6f).