In contrast, high grade meningioma samples were enriched in FOXM1 target genes along the first principal component, and were further delineated along the second principal component by expression of either neuronal or immune genes, the latter of which included increased PD-1 signaling and regulators of ectodermal development such as CTNNB1, RELA, EED, and STAT6 targets (Fig. 1b and Supplementary Fig. 1a). This evidence concerns the gene EED and meningioma.