PTPRZ1 and glioblastoma: Within these gene sets, notable genes that were enriched in samples with high ADC values included CDH2, which encodes N-cadherin and is a regulator of noncanonical Wnt signaling and neuronal development39,40, and PTPRZ1, which is necessary for neuronal development41, and we and others have shown is involved in glioblastoma cell invasion and self-renewal42–44.