BM transplant from Ddit3−/− mice into hypertensive vitamin D-deficient Ddit3+/+ mice decreased SBP, DBP, and plasma renin compared to BM transplant from Ddit3+/+ mice (Fig. 3n, o), confirming that activation of the ER stress PERK/CHOP pathway by inactivation of macrophage VDR signaling increases miR-106b-5p secretion and renin-dependent hypertension. This evidence concerns the gene REN and Hypertension.