Lethally irradiated KODMAC mice transplanted with bone marrow from other KODMAC (KOD→KOD) or control mice (Con→KOD) demonstrated that restoration of myeloid VDR could prevent hypertension, with 20–28 mmHg lower BP (Fig. 1h) and a 36% reduction in plasma renin (Fig. 1i) after 8 weeks in Con→KOD mice compared to KOD→KOD mice. This evidence concerns the gene REN and hypertensive disorder.