REN and hypertensive disorder: We found that the absence of miR-106b prevented the SBP and DBP elevation, increased plasma renin, and stimulation of Ren1c-YFP JG renin production by KODMAC macrophages, suggesting that KODMAC macrophage secretion of miR-106b-5p increases RAS-dependent hypertension in vivo (Fig. 3e–g).