To further test whether the GPC3-synNotch-inducible CD147-CAR cells can control progression of HCC in vivo, 1.3 × 106 irradiated GPC3-synNotch-inducible CD147-CAR-NK-92MI cells with 2 × 104 IU IL-2 were adoptively transferred intraperitoneally (i.p.)into the CD147+GPC3high HepG2 and CD147+GPC3low HepG2 inoculated xenograft NSG mice (Supplementary Fig. 16). Here, IL2 is linked to hepatocellular carcinoma.