To test whether the toxicity that may result from GPC3-synNotch-inducible CD147-CAR targeting of CD147 in healthy tissues, we generated a hCD147TG mouse model to test the on-target/off-tumor toxicity of GPC3-synNotch-inducible CD147-CAR-NK-92MI treatment of HCC (Supplementary Fig. 17). This evidence concerns the gene GPC3 and neoplasm.