To test whether the on-target/off-tumor toxicity of GPC3-synNotch-inducible CD147-CAR-NK-92MI cells, non-tumor-bearing hCD147TG mice were treated with in vitro activated, primed, and irradiated GPC3-synNotch-inducible CD147-CAR-NK-92MI cells. Here, GPC3 is linked to neoplasm.