CDC37 and neoplasm: Among the numerous molecular chaperones of Hsp90, the value of cell division cycle protein 37 (Cdc37) has attracted much attention.110 Many protein kinases (such as EGFR, CDK, Akt) rely on Cdc37 to aggregate onto Hsp90, thus completing the correct folding of the complex’s spatial conformation.110,119 Therefore, inhibiting the interaction of Hsp90 and Cdc37 may deactivates the kinase client proteins, thereby inhibiting the proliferation and growth of tumor cells.