Hence, blocking CySSCy import via xCT (i.e. by erastin), synthesis of GSH (i.e. by buthionine sulfoximine, BSO) or GPx4 activity (i.e. by RAS-selective lethal 3, RSL3) proved to induce accumulation of membrane lipid peroxides within different cancer cell types, further inducing the loss of membrane assembly, structure, dynamics, and finally, cell death (ferroptosis)42,43. This evidence concerns the gene GPX4 and cancer.