FGF2 and Alzheimer disease: Chord plots of AD induction (Fig. 7d–f) performed by the DEGs of Rap1 signaling pathway and top 15 of GO terms in each group, showed that FGF2 was mainly enriched in the protein binding, growth factor activity, cytoplasm, nucleus, extracellular space, extracellular region, signal transduction, positive regulation of cell proliferation, and positive regulation of cell proliferation.