The transcriptional crosstalk between mutant p53, MYC/MYC signature and immune signature was assessed in two HNSCC cell lines, Cal-27 and Detroit-562 cells, As expected, both mutant p53 and MYC depletion reduced the expression of two MYC target genes, HPRT1 and CSTF2 (Fig. 3d-e). The gene discussed is HPRT1; the disease is head and neck squamous cell carcinoma.