BRAF and melanoma: To expand the analysis of the miR involved in establishing a resistant phenotype, we analyzed the miR expression profiles of six melanoma cell lines which developed acquired resistance to vemurafenib (PLX4032) and cross resistance to dabrafenib (BRAFi), trametinib (MEKi) and the combination of dabrafenib and trametinib (BRAF/MEKi) and their parental drug-sensitive counterparts (supplementary Fig. S1A).