Notably, miR-146a upregulation with concomitant increased COX2, PDL1, VEGFA, CCL2, IL6, IL8 and MCL1 expression characterized the MDSCs induced in vitro by melanoma extracellular vesicles from monocytes from healthy donors, suggesting cell type-specific regulation of the miR-146a/COX2 axis. This evidence concerns the gene IL6 and melanoma.