In breast carcinoma cells, DCN had an anti-angiogenic effect while BGN in bone fractures increased pro-angiogenic signals such as VEGFA (vascular epithelial growth factor A) showing that BGN and DCN have antagonistic effects, thus explaining the difference in CSPG4 expression between bBGN and bDCN in PERI cells [62, 63]. This evidence concerns the gene VEGFA and breast carcinoma.