According to a previously published study, the TIME can be divided into 4 subtypes determined by the levels of molecules and cells related to TIME, including programmed death-ligand 1 (PD-L1) and tumor infiltrating lymphocytes (TILs); these consist of Type I (PD-L1-, TILs-), Type II (PD-L1+, TILs+), Type III (PD-L1+, TILs-) and Type IV (PD-L1-, TILs+) [8]. The gene discussed is CD274; the disease is neoplasm.