Circular gastric antrum neuromuscular strips were mounted and incubated in hyperglycemia in the absence or presence of 17β-estradiol (E2) (Fig. 4a), progesterone (Fig. 4b), or selective ER agonists, PPT (Fig. 4c) or DPN (Fig. 4d). The gene discussed is ESR1; the disease is Hyperglycemia.