TTR gene sequencing should be performed in cases of progressive polyneuropathy of seemingly unknown cause accompanied by one of the following red flags: autonomic dysfunction or gastrointestinal disorders, bilateral carpal tunnel syndrome, unexplained weight loss [1, 82], early gait disability [66], or CIDP refractory to intravenous immunoglobulin therapy [1]. The gene discussed is TTR; the disease is carpal tunnel syndrome.