NPPA and myocardial infarction: A reduced release of myocardial creatinine kinase isoform MB by ~15%, an increase in left ventricular ejection fraction by ~5%, and a decrease in reperfusion injuries (defined as malignant arrhythmias, re-elevation of ST-segment, or worsening of chest pain) have been reported in a clinical placebo-controlled trial on ANP infusion during MI [110].