Cheng at al. have described an anticancer activity of prodigiosin in human glioblastoma (GBM) cells and suggested this compound to activate autophagy in GBM cells via the activation of JNK and simultaneous inhibition of AKT/mTOR pathways, which was probably related to the prodigiosin-induced ER stress [96]. The gene discussed is MTOR; the disease is glioblastoma.