Analysis of TFs identified the most significant central hubs consisting of JUN, STAT3, YY1, PPARG, EGR1, CREB1, GATA3, SREBF2 and ELK1 as common regulators, which were mainly enriched in the viral infection, including PPAR, AMPK and JAK-STAT signaling pathways (Figure 3). This evidence concerns the gene STAT3 and viral infectious disease.