SOD1 and amyotrophic lateral sclerosis: In this study, we first compared all the DEGs together among FUS- and SOD1-ALS datasets (present study vs. GSE106382) and our analysis showed that gene expression profiles of subjects with FUS and SOD1 (present study) did not overlap with those affected by FUS and SOD1 (GEO dataset) (Figure 1B); however, significant overlaps of DEGs were identified when systematically comparing them with their respective or mutual counterparts, suggesting that similar functional and/or molecular changes occur in these disease subtypes.