Adding on to the aforementioned results, we identified 19 shared TFs (JUN, STAT3, GATA3, GATA2, CEBPB, SREBF2, STAT1, YY1, HNF4A, RELA, E2F4, CREB1, MEF2A, TFAP2A, ESR1, PPARG, RUNX1 and ELK1) with high degrees between two FUS-ALS datasets (present study vsGSE106382) that are linked to prion diseases, transcriptional regulation, viral infection and PPAR signaling pathways. This evidence concerns the gene ESR1 and amyotrophic lateral sclerosis.