Furthermore, a comprehensive and systematic screening of FUS and SOD1 transcriptomes utilizing the publicly available microarray data GSE106382 [23], to further analyze the common molecular determinants from 2 FUS-ALS iPSC lines, two SOD1-ALS lines and four healthy controls identified a total of 884 DEGs in FUS samples compared with control samples, and a total of 1680 DEGs in SOD1 samples vs. healthy individuals, including 327 common DEGs shared between FUS and SOD1. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.