Analysis of TFs identified the most significant central hubs consisting of JUN, STAT3, YY1, PPARG, EGR1, CREB1, GATA3, SREBF2 and ELK1 as common regulators, which were mainly enriched in the viral infection, including PPAR, AMPK and JAK-STAT signaling pathways (Figure 3). The gene discussed is CREB1; the disease is viral infectious disease.