Owing to the observed dysregulation of DEGs, including zinc finger proteins and RNA/ribosome binding proteins known to associate the viral interaction with host and the MAPK cascade, speculatively HSV infection involvement might have a quick fire role in activating MAPK-associated signaling pathways and TFs like ZNFs, thereby triggering inflammatory dependent manifestations seen during the FUS–ALS disease course. Here, ZNF146 is linked to amyotrophic lateral sclerosis.