TP53 and amyotrophic lateral sclerosis: Comparisons of FUS- and SOD1-ALS DEGs (versus healthy controls) in our datasets identified only few common signaling pathways associated with ubiquinone/quinone biosynthesis and SNARE interactions in vesicular transport, whereas the common DEGs (GSE106382) were found to be significantly enriched in amino acid metabolism, p53 signaling pathway and NF-kappa B signaling pathways, indicating that common mechanisms may be involved between these diseases (Figure S2C).