PPI analysis identified hub genes with highest degrees TRIM28, MET, JAK2, UBC, MAPK1/MAPK3, PLK3CG, GSK3B, PLCG1, ZAP70 and NCOA2 shared between two FUS-ALS datasets, suggesting a critical role of these genes/proteins as potential transcriptomic regulators for FUS-ALS (Figure 4C) that may regulate many cellular activities, including cellular differentiation, proliferation, apoptosis, inflammation and innate immunity. The gene discussed is UBC; the disease is amyotrophic lateral sclerosis.