PIK3CA and amyotrophic lateral sclerosis: In the present study, the unique interactome (94 annotated genes, 272 nodes, 3877 edges, PPI enrichment p-value = < 1.0 × 10−16) of dysregulated genes were significantly enriched in cell cycle, proteasome, SNARE interactions (soluble N-ethylmaleimide-sensitive factor attachment protein receptors), cell adhesion, PI3K-AKT/MAPK, stress response, ER-Golgi network and mitochondrial mitophagy, consistent with a role for SOD1 in ALS pathogenesis (Figure S4C).