FUS and amyotrophic lateral sclerosis: Similarly, the gene expression of GSE106382 datasets obtained from GEO database detected a total of 884 DEGs in FUS and 1680 DEGs in SOD1 samples (p-value < 0.05, FC ≥ 1.5) of ALS patients compared to controls, of which 327 overlapping DEGs were identified for both datasets, which were involved in the biological process related to ALS (Figure 2A).