Adding on to the aforementioned results, we identified 19 shared TFs (JUN, STAT3, GATA3, GATA2, CEBPB, SREBF2, STAT1, YY1, HNF4A, RELA, E2F4, CREB1, MEF2A, TFAP2A, ESR1, PPARG, RUNX1 and ELK1) with high degrees between two FUS-ALS datasets (present study vsGSE106382) that are linked to prion diseases, transcriptional regulation, viral infection and PPAR signaling pathways. The gene discussed is ESR1; the disease is viral infectious disease.