Similarly, the gene expression of GSE106382 datasets obtained from GEO database detected a total of 884 DEGs in FUS and 1680 DEGs in SOD1 samples (p-value < 0.05, FC ≥ 1.5) of ALS patients compared to controls, of which 327 overlapping DEGs were identified for both datasets, which were involved in the biological process related to ALS (Figure 2A). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.