In line with our findings, interactome analysis of GSE106383 dataset revealed that the ribosome and mitochondrial factors were highly enriched among destabilized transcripts in both FUS- and SOD1-ALS iPSCs, indicating a conserved gene expression pattern of RNA destabilization between different ALS types, and their connections dysregulated protein synthesis and/or ribosomal biogenesis pathways. Here, FUS is linked to amyotrophic lateral sclerosis.