While the analysis of FUS-ALS DEGs identified in the GSE106382 dataset retrieved many significant clusters in the interactome (PPI enrichment p-value ≤ 1.0 × 10−16, 969 nodes, 6171 edges) with the original seed of 884 annotated DEGs, ribosomal protein L31 (RPL31) was the most highly ranked hub gene revealing the major interconnected cluster among the dysregulated genes (Figure S4B). Here, RPL31 is linked to amyotrophic lateral sclerosis.