In cluster analysis, genes such as RPL31, RPS4Y1, PSMD10, MAPK9, CDC7, MET, RANBP2, JAK2, GNAS, PLCB1 and VAMP8 were unveiled as hub genes with the highest node degree in significant clusters, the topmost clusters being ribosome (RPSL31, RPL35A), immune system (JAK2) and MAPK/PI3-AKT (MAPK9) signaling incidentally all associated with FUS-ALS. Here, GNAS is linked to amyotrophic lateral sclerosis.