On the other hand, interactome analysis of common 16 DEGs in SOD1-ALS (present study vs. GSE106382) identified a tyrosine-protein kinase receptor ret (RET; betweenness centrality = 894; degree = 38) network enriched in pathways associated with ErbB signaling, neurotrophin and focal adhesion (Figure 4D). This evidence concerns the gene BDNF and amyotrophic lateral sclerosis.