Overall, taking the advantage of iPSC model system and by integrating the recent published data (such as the one presented here), our study provides a unique set of data comparing the transcriptomic alterations and/or events found in MNs from FUS and SOD1-ALS patients and controls, revealing conserved signatures/risk factors in viral infection, ribosome/protein translation and cell adhesion processes. This evidence concerns the gene FUS and viral infectious disease.