SOD1 and amyotrophic lateral sclerosis: The PPI (four annotated genes in the present study; 203 nodes and 2445 edges) represented in the common network for FUS- and SOD1-ALS identified only one hub gene SNAP23 (betweenness centrality = 276; degree = 24) having a significant number of interacting partners associated with the SNARE interactions in vesicular transport, providing evidence for a conserved functional role of FUS and SOD1 in the vesicle:organelle-mediated membrane trafficking processes during the development of the nervous system (Figure 4A).