AKT1 and amyotrophic lateral sclerosis: Furthermore, PPI network analysis of DEGs in SOD1-ALS revealed an interactome with significant functional clusters centered on genes were enriched in tyrosine protein kinase family of proteins, vesicular transport, cell adhesion and MAPK/PI3K-AKT signaling pathways, all of which form the basis for neuronal death or repair (Figure S4).