Comparison of FUS- and SOD1-ALS datasets (present study vs. GSE106383) revealed 16 DEGs common to the datasets of FUS- and SOD1-ALS getting significantly visibly associated with biological processes and molecular functions, viz., cell–cell signaling, receptor protein tyrosine/kinase activity, synaptic transmission, cell–cell adhesion and ion binding. Here, SOD1 is linked to amyotrophic lateral sclerosis.