Even though PPARG and its roles in mitochondrial biogenesis and cell survival in neurons through PPARG coactivator 1α (PGC-1α), are well documented with the neuroprotective effects of PPARG agonists well worked out in ALS [85,90,91], its role in lipid metabolism and this aspect in FUS-ALS needs attention. Here, PPARG is linked to amyotrophic lateral sclerosis.