Similarly, for SOD1-ALS DEGs (GSE106382), major altered pathways included the morphine addiction pathway, synapse related functions, metabolic processes and epidermal growth factor receptor (EGFR/ErbB) signaling pathway (Figure 2B, Table S3), suggesting the impacts of metabolic requirements and neuronal mechanisms in this disease. Here, SOD1 is linked to amyotrophic lateral sclerosis.