In cluster analysis, genes such as RPL31, RPS4Y1, PSMD10, MAPK9, CDC7, MET, RANBP2, JAK2, GNAS, PLCB1 and VAMP8 were unveiled as hub genes with the highest node degree in significant clusters, the topmost clusters being ribosome (RPSL31, RPL35A), immune system (JAK2) and MAPK/PI3-AKT (MAPK9) signaling incidentally all associated with FUS-ALS. This evidence concerns the gene PLCB1 and amyotrophic lateral sclerosis.