MET, a transmembrane receptor kinase-mediated PI3-AKT and MAPK signaling pathway mitigating the regulation of neuronal development, differentiation, motility, migration of neuronal precursors and survival also linked to ALS pathophysiology [62,63,64,65,66] with the definitive status of MET as a potential marker of FUS-ALS needing to be corroborated with validation studies. This evidence concerns the gene MET and amyotrophic lateral sclerosis.