MIF and early-onset autosomal dominant Alzheimer disease: The macrophage migration inhibitory factor (P30904) is a cytokine of 12.5 kD that regulates the immune response and has the expression increased in traumatic brain injuries and other pathological conditions as multiple sclerosis, meningitis and Alzheimer’s disease [40,41,42,43] and it was found upregulated in our proteomic approach.