More recently, the concept of “tumor-associated immune dysregulation” has been introduced to describe tumor cell capability to hijack the wound healing program and generate—via pro-angiogenic (i.e., Vascular Endothelial Growth Factor (VEGF), Fibroblast Growth Factor (FGF), and IL-8) and immunosuppressive (primarily IL-10 and TGF-β) cytokines—a permissive microenvironment enabling immunosurveillance escape and tumor growth. The gene discussed is CXCL8; the disease is neoplasm.