They found that elevated circulating levels of MCP-1, IL-2R, IL-15, and IL-8 predicted poor anemia response and that increased levels of sIL-2R, IL-15, and MCP-1 clustered with splenomegaly, which in turn associated with impaired hemoglobin raise during treatment [69]. Here, CXCL8 is linked to Splenomegaly.