SOAT1 and myeloproliferative disorder: In addition to driver mutations, several other genetic hits have been associated with MPN (including TET2, ASXL1, IDH1/2, EZH2, SRSF2, LNK, CBL), many of them holding prognostic relevance and variably converging on the activation of JAK/STAT signaling [32], which configures as the common denominator between MPNs and the signaling components of the inflammatory cytokine pathway.