Cytokine-phenotype associations included (i) IL-8 with constitutional symptoms, increased leukocytes and peripheral blasts, leukemic evolution; (ii) IL-2R, IL-12, and transfusion need; IP-10 and thrombocytopenia; HGF, MIG, IL-1RA, and marked splenomegaly [68]. This evidence concerns the gene CXCL8 and Splenomegaly.