SLC8B1 and Alzheimer disease: This work also evaluated available microarray and RNA-Sequencing datasheets to analyse the expression of mitochondrial Ca2+-related genes in patients with AD and found that all the genes involved in mitochondrial uptake were downregulated, while Slc8b1 gene encoding NCLX was significantly upregulated, suggesting a possible compensatory response to prevent mitochondrial Ca2+ overload [126].