SOCS3 and cancer: It was further shown that these lncRNAs interacted with ELF1 and E2F1, respectively, to trans-regulate several chemoresistance-related genes such as Glutathione S-Transferase Pi 1 (GSTP1), BTG Anti-Proliferation Factor 3 (BTG3), Suppressor of Cytokine Signaling 3 (SOCS3), and breast cancer susceptibility gene (BRAC2) [235].