SMAD1 and breast cancer: Moreover, miR-155 delivered by exosomes augmented EMT and conferred chemoresistance to recipient BC cells, by regulating at least five genes: adenomatous polyposis coli (APC), Hydroxysteroid 17-Beta Dehydrogenase 12 (HSD17B12), MYC, Mothers against decapentaplegic homolog 1 (SMAD1), and SMAD3 [132].