The experimental induction of lncRNA H19 was shown to attenuate paclitaxel-induced apoptosis in ERα-positive BC via epigenetic regulation of the key pro-apoptotic genes BCL2 Interacting Killer (BIK) and Phorbol-12-myristate-13-acetate-induced protein 1 (NOXA) in an EZH2-dependent manner [229]. Here, BIK is linked to breast cancer.