More recently, Takai et al. carried out a genome-wide RNAi through the GeneNet h50K shRNA library, which is composed of ~200,000 lentiviral shRNAs and more than 47,000 transcript targets, in order to identify genes with a synthetic lethal interaction with epithelial cellular adhesion molecule (EpCAM) as a potential therapeutic target for the EpCAM + AFP + Hepatocellular carcinoma subtype [75]. The gene discussed is EPCAM; the disease is hepatocellular carcinoma.