Although the pathomechanisms of tauopathy in neurodegeneration have not been fully elucidated, the phosphorylation theory of tauopathy is based on diverse processes, including tau phosphorylation, proteolysis, oligomerization, and aggregation that leads to the formation of paired helical filaments and neurofibrillary tangles [24]. The gene discussed is MAPT; the disease is tauopathy.