For example, a 2020 clinical study investigating insulin sensitivity (with the use of a hyperinsulinemic–euglycemic clamp) of non-obese versus obese individuals with T2DM demonstrated that insulin sensitivity (determined by the ratio of metabolic rate to steady-state insulin) was more than two-times greater in non-obese than obese individuals with T2DM (p < 0.05) [21]. This evidence concerns the gene INS and type 2 diabetes mellitus.