The interplay between differentially expressed lncRNAs, such as MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) and CDKN2B-AS1 (cyclin-dependent kinase inhibitor 2B antisense RNA 1), and histone-modifying or chromatin-remodeling complexes has been implicated in transcriptional regulation, enabling progression of different cancer types [24]. This evidence concerns the gene MALAT1 and cancer.