SP4 and colorectal cancer: In colorectal cancer (CRC), the SRSP (splicing regulatory small protein) encoded by the lncRNA Loc90024 interacts with SRSF3 and promotes its binding to SP4. SRSF3-SRSP mediates the alternative splicing of SP4 and generates cancerous SP4 isoforms, leading to tumorigenesis and metastasis [44].