The epithelial Exo70 variant can affect the expression levels of EMT-related genes, such as those encoding Snail and ZEB2, inducing the epithelial phenotype and inhibiting tumor metastasis in breast cancers; in contrast, the mesenchymal Exo70 variant cooperates with the Arp2/3 complex to enhance tumor invasion by inducing actin polymerization [181]. The gene discussed is ZEB2; the disease is neoplasm.