Functionally, LIN28-mediated let-7 downregulation derepresses the target genes of let-7, which include K-Ras, c-Myc, HMGA1, HMGA2, VEGF, PDK1, Cyclin D, BMP4, IL-6, IGF1R, and IGF2BP2. Eventually, LIN28/let-7 pathway leads to cancer development and progression-related phenotypes, including proliferation, invasion, metastasis, tumor-promoting inflammation, and angiogenesis [14,15]. Here, HMGA1 is linked to cancer.