HIPK2 and colonic neoplasm: In colon cancer cells, SRSF3 regulates the alternative splicing of HIPK2. Research revealed that SRSF3 depletion promotes skipping of 81 5′ nucleotides (27 amino acids) from exon 8 of HIPK2. This generates HIPK2 Δe8, which has no binding site for SIAH1 ubiquitin ligases, and is thus protected from proteasomal digestion [40].