VEGFA and malignant colon neoplasm: Depletion of sTIA-1 or overexpression of full-length TIA-1 (flTIA-1) increases the generation of the anti-angiogenic isoform, VEGF-A165b, leading to decreased tumor formation and vascularization in colon cancer xenografted mice, compared to those overexpressing sTIA-1 [167].