To understand the functional role of Arid1a in development of pancreatic cancer, we generated LSL-KrasG12D; Arid1afl/fl; Ptf1a-Cre (“KAC”) mice by crossing Arid1afl/fl; Ptf1a-Cre (“AC”) mice with Lox-stop-lox KrasG12D mice [9]. The gene discussed is PTF1A; the disease is pancreatic neoplasm.