ARID1A and keratoconus: The isogenic CRISPR-ARID1A clones of “KC” and “KPC” cells were strikingly different in their behavior from the autochthonous “KAC” PDAC lines, which can be postulated to arise through an “escape” phenomenon from Arid1a deletion-induced growth constraint in vivo, likely under the selection pressure of oncogenic Ras and other secondary events within the pancreatic epithelium.