Impaired glycolysis is also evident in various immune cell subsets in MS: B cells and antibodies reactive with glycolysis enzymes triose phosphate isomerase (TPI) and Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) were shown to be present intrathecally in CSF and MS lesions (Figure 3) [65]. This evidence concerns the gene TPI1 and myeloid sarcoma.