Khor et al. testified that Nrf-2 knockout mice with azoxymethane and DSS administration showed greater tumor incidence (80% versus 29%, respectively) as well as an augmentation of inflammatory markers like Cox-2, 5-lipoxygenase, PGE-2, and leukotriene levels in colon as compared with azoxymethane and DSS-treated wild-type (WT) mice [36]. Here, PTGS2 is linked to neoplasm.