MAPT and neurodegenerative disease: FTD consists of a spectrum of clinical syndromes associated with several underlying neurodegenerative diseases characterized by frontotemporal lobar degeneration (FTLD) [45] and neuropathologically, most (90–95%) FTLDs are caused by intracellular aggregates of p-tau or TAR DNA-binding protein 43 (TDP-43) [46].