When the DNAm level of the LRRC37A4 promoter is low, the transcription factor and promoter are combined, thereby promoting the expression of LRRC37A4 (DNAm–gene effect value bSMR = −0.1 and −0.09, respectively) and increasing the risk of PD (gene–PD effect value bSMR = 1.58). This evidence concerns the gene LRRC37A4P and Parkinson disease.