Of the eight genes analyzed by SMR, SNCA [43,44], CRHR1 [27,28], KANSL1 [27], LRRC37A [29], BST1 [30,31,32,33] and DGKQ [32] have been shown in previous studies to be related to PD at the genome-wide level (Table 1). Here, CRHR1 is linked to Parkinson disease.