CRH and Parkinson disease: Notably, a recent genetic analysis involving 8725 PD patients and 17,079 controls found that BST1 is a susceptibility gene for PD [33], and previous experiments in BST1 knockout mice suggested that the gene might be beneficial in promoting treatment for PD [34]; the top negatively related gene CRHR1, as a target for a hydrocortisone drug for Cushing’s disease [35], is also known as the corticotropin releasing factor (CRF) receptor 1, and there is evidence that CRF and its receptors protect neurons [36,37].