LPS- and NF-kB (p50/p65)-inducible microRNAs, such as miRNA-146a and miRNA-125b, appear to contribute to neuropathological, neuro-inflammatory, and altered neuro-immunological aspects of both AD and prion disease (PrD; [25,32,40,46,48,49,50]). This evidence concerns the gene NFKB1 and prion disease.