CFH and Alzheimer disease: An inducible miRNA-146a: (i) is significantly up-regulated in AD brain tissues, CSF, and blood serum [25,48]; (ii) is an important epigenetic modulator of inflammatory signaling and the innate-immune response in several neurological disorders; and (iii) is essential in the down-regulation of the innate-immune regulator complement factor H (CFH; [10,20,23,25,40,46,49]).