The conformationally stable SARS-RBD has a smaller number of kinetically active and adjoining residues (SAGNM predictions) in direct contact with ACE2 (Figure 8a–c), while SAGNM predictions in COVID-19 RBD are directly oriented and are in contact with the active residues in ACE2 (Figure 8d–f). The gene discussed is ACE2; the disease is COVID-19.