Taken together our observations suggest that RASSF1A acts as an inhibitor of ERα driven breast cancer cell growth through a complex, hierarchically organized network that involves first suppression of the Hippo effector YAP1 and subsequent inhibition of AKT1, increased FOXO3A activity as well as the blockade of FOXM1 and ERα expression, thereby inducing growth arrest and senescence. The gene discussed is FOXO3; the disease is breast carcinoma.