Thus, the loss or inhibition of RASSF1A that is observed in many types of cancer [40] would be predicted to disturb the homeostatic regulation of FOXM1 and FOXO3A, leading to oncogenic stimulation through deregulated FOXM1 activity, which explains why the loss of RASSF1A can contribute to cancer initiation and progression. The gene discussed is RASSF1; the disease is cancer.