In our study, noticeable changes in participants in the tear expression profile of the IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, and IL-10, with a statistically significant elevation of the chemokine IL-8 in the POAG patients respect to the CG (Figure 3A–G, respectively) were observed. This evidence concerns the gene IL4 and open-angle glaucoma.