Lipopolysaccharide‐binding protein (LBP), sCD14, ubiquitin C‐like protein (UBC), ubiquitin thioesterase protein (OTUB1), transferrin receptor (TFRC), beta‐2‐microglobulin (B2M), cystatin (CST3) and FGA were up‐regulated in the MDR‐TB group and the DS‐TB group, compared with the HC group. This evidence concerns the gene UBC and multidrug-resistant tuberculosis.