NES and acute myeloid leukemia: The persistence of nestin+ cells in highly infiltrated BM of AML patients and mice suggested that these cells may actively contribute to disease progression, possibly by providing support to leukemic blasts, as previously suggested for other stromal cells, albeit through in vitro rather than in vivo studies (Brenner et al., 2017; Corradi et al., 2018; Geyh et al., 2016; Kornblau et al., 2018; Wu et al., 2018; Yehudai-Resheff et al., 2019).