For that purpose, nestin+ cell depletion was combined with cytarabine (AraC—a chemotherapeutic drug frequently used in AML therapy) (Burnett et al., 2011; Tamamyan et al., 2017) in mice transplanted simultaneously with WT and iMLL-AF9 cells (Figure S1H). The gene discussed is NES; the disease is acute myeloid leukemia.