Intriguingly, mRNA expression of the catalytic subunit of gamma-glutamylcysteine synthetase (Gclc), which is the first rate-limiting enzyme of GSH synthesis, was reduced in AraC-treated AML blasts cocultured with BMSCs (Figure 6A), arguing against de novo GSH synthesis stimulated by BMSCs. This evidence concerns the gene GCLC and acute myeloid leukemia.