PTPRC and leukemia: To directly compare the role of nestin+ cells in normal hematopoiesis and leukemia development, Nes-creERT2;iDTA and their littermate iDTA controls were competitively transplanted with WT BM cells and non-induced iMLL-AF9 BM cells, allowing simultaneous monitoring of normal and leukemic hematopoiesis, which were distinguished in the same animal by the expression of different CD45 surface marker isoforms (Figure 2A).