Although TRI MP treated mice did not have a significantly different FoxP3-CD25+ cell population relative to PBS and Blank MP controls (Fig 6C), the average for TRI MP was slightly larger driven by three TRI MP treated mice with arthritis scores of zero and greater than 20% of CD4 T cells expressing the FoxP3-CD25+ phenotype (Fig 6C). The gene discussed is CD4; the disease is arthritic joint disease.