As such, we postulate that a loss of melanin in melanoma tumor tissue in AHM may occur due to loss of heterozygosity (LOH) or somatic mutation of the functional copy of the TYR or OCA2 genes, with the remaining deleterious albinism allele(s) leading to a deficiency in melanogenesis or the observed lack of pigment. This evidence concerns the gene OCA2 and neoplasm.