OCA2 and melanoma: However, compared to combined controls (3.13% BNMS/2.04% MGRB), there was a highly significant greater occurrence of TYR+OCA2 deleterious alleles in total melanoma cases (SMMAT P = 0.008), but not AHM (SMMAT P = 0.90), nor in comparison between AHM and PM (SMMAT P = 0.095).