In the present collection, rare variant burden tests showed that familial and population-based cutaneous melanoma patients tended to have higher frequencies of rare germline variants in albinism genes including TYR and OCA2. Of further significance, our study demonstrated that rare variants of TYR and the OCA2 p.V443I allele were even more frequent in individuals with AHM as compared to those with PM. Here, TYR is linked to albinism.