Multiomics single-gene studies on the candidate oncogene AHNAK2 have enriched our understanding of the molecular function of AHNAK2 and have provided a new piece of the puzzle to the mechanism of cancer development and a basis for subsequent research on AHNAK2. The significant diagnostic and prognostic value of AHNAK2 may also be used in clinical practice to assist doctors in the diagnosis and treatment of PTC patients. This evidence concerns the gene AHNAK2 and cancer.