Specifically, KLF5 promotes the migration of bladder cancer cells [7,11], breast cancer cells [10,20], mouse primary esophageal keratinocytes [9], bronchial smooth muscle cells [21] and intestinal epithelial cells [22]; in contrast, KLF5 inhibits the migration of HaCaT cells, MCF-10A cells [23] and mouse PDA cells [24]. The gene discussed is KLF5; the disease is urinary bladder cancer.