In terms of cell migration, KLF5 can promote keratinocyte migration by inducing integrin-linked kinase and can promote bladder cancer cell and breast cancer cell migration by upregulating the tyrosine-protein kinase Fyn (FYN) and TNF alpha-induced protein 2 (TNFAIP2), respectively [9–11]; in contrast, KLF5 loss can also drive the invasive progression of human squamous cell cancers in the context of p53 ablation [12], and epithelial cell migration is accelerated after KLF5 knock-down [13]. This evidence concerns the gene KLF5 and squamous cell carcinoma.