ZNRF3 and cancer: Wnt pathway activation by the representative oncogenic variant RNF43 R519X remained unaffected by PORCN inhibitors, while these compounds fully suppressed Wnt signaling activity induced by the LOF cancer mutant I48T or by RNF43/ZNRF3 deletion (Figs 1G and EV1B) (Jiang et al, 2013).