MAPK8 and cardiac hypertrophy: Furthmore, Sop treatment under PE stimulation also showed no changes in the phosphorylation levels of (p38, JNK, ERK) and NFAT3 nuclear translocation, compared with corresponding controls, respectively (Figure 5A,B), indicating that Sop did not alleviate cardiac hypertrophy via MAPK or NFAT3 signaling.