ABCA1 and Alzheimer disease: Alterations of the expression or activity of efflux transporters (e.g., low‐density lipoprotein receptor‐related protein 1 [LRP1], P‐glycoprotein [P‐gp], and adenosine triphosphate [ATP]‐binding cassette transporter A1 [ABCA1]) and the influx transporter receptor for advanced glycation end products (RAGE) were observed in AD patients and mouse models, resulting in impairments in the clearance of Aβ (Chiu et al., 2015; Elali & Rivest, 2013).