Previous studies showed that the inhibition of NLRP3 inflammasome promoted the transformation of microglia to M2 type and enhanced the clearance of Aβ as well as spatial memory in AD mice (Heneka et al., 2013). Since Klotho can reduce NLRP3/caspase‐1 signaling pathway, we speculated that Klotho can promote the transformation of microglia to M2 type. This evidence concerns the gene NLRP3 and Alzheimer disease.