GFAP and nervous system disorder: Moreover, alterations in brain-derived IL-2 and IL-2 receptors, potentially produced by neurons and astrocytes (Shen et al. 2010), have been implicated in the pathogenesis of several major neurological disorders due to their immunoregulatory functions (Wei et al. 2014); among these, the ability to drive GFAP+ astrocyte-targeted production of IL-10, which in turn modulates the numbers of microglia/macrophages, has been postulated (Recasens et al. 2019).