In this study, we will study the effects of sidt2 on insulin-stimulated glucose uptake in 3T3-L1 adipocytes, C2-C12 myoblasts, and HEPA1-6 hepatoma cells, and on IRS-1-PI3-K-Akt signaling pathway, in order to reveal the effect of sidt2 on cellular insulin resistance and its possible molecular mechanism, and provide a new direction for the diagnosis and treatment of type 2 diabetes. Here, IRS1 is linked to Insulin resistance.