And those upregulated overlapping DEGs PRR11, FZD3, TMTM178B, CACNA1D, and SERPINE1 were correlated with has-miR-500a-3p, has-miR-29c-5p, has-miR-486-5p, and has-miR-145-5p, respectively, in COAD as shown in Figure 7. The gene discussed is SERPINE1; the disease is colon adenocarcinoma.