Furthermore, 8 differential expression genes (DEGs) (CACNA1D, DTNA, FZD3, PRR11, RPS6KA5, SERPINE1, TMEM178B, and TUBB6) correlated with 7 DEMs (has-miR-15b-3p, has-miR-144-5p, has-miR-130-3p, has-miR-500a-3p, has-miR-29c-5p, has-miR-486-5p, and has-miR-145-5p) were related to the survival rate of COAD, of which 6 genes (CACNA1D, DTNA, SERPINE1, TUBB6, FZD3, and RPS6KA5) were associated with pathologic TNM. The gene discussed is SERPINE1; the disease is colon adenocarcinoma.