MCM6 could predict the poor OS (HR = 2.04, P = 0.0316), RFS (HR = 1.74, P = 0.0258), PFS (HR = 1.7, P = 0.0218), and DSS (HR = 2.26, P = 0.0469) in HCC patients with hepatitis virus infection. The gene discussed is MCM6; the disease is hepatocellular carcinoma.